Endostatin inhibits murine colon carcinoma sinusoidal-type metastases by preferential targeting of hepatic sinusoidal endothelium
نویسندگان
چکیده
منابع مشابه
Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4‑induced fibrosis in mice.
The aim of the present study was to detect the effect of the recombinant human endostatin Endostar on hepatic sinusoidal capillarization in CCl4‑induced murine models of liver fibrosis. The liver fibrosis model was induced in BALB/c mice using intraperitoneal injection of CCl4 for 6 weeks. Animals were divided into the following six treatment groups: Group 1, normal animals; group 2, CCl4‑induc...
متن کاملTakayasu arteritis associated with hepatic sinusoidal dilatation.
Hepatic sinusoidal dilatation (HSD) is pathological entity that is characterized by peliosis hepatis (PH) like lesions, with vascular lesions that consist of multiple cyst-like, blood-filled cavities within the liver. To the best of our knowledge, neither PH nor HSD have been associated with systemic vasculitis. We describe herein two cases of idiopathic HSD associated with Takayasu arteritis (...
متن کاملSinusoidal portal hypertension in hepatic amyloidosis.
Hepatic venous catheterisation and transvenous liver biopsy were performed in five patients with hepatic amyloidosis. In three patients, hepatic venous pressures were normal and histological examination of the liver biopsy specimen showed discrete and sparse perisinusoidal amyloid deposits. In the other two, however, the gradient between wedged and free hepatic venous pressures was increased (1...
متن کاملMigration of liver sinusoidal leukocytes to the liver colon adenocarcinoma metastases
Introduction Liver is an organ with three populations of host cells reacting with tumor cells. These are the Kupffer cells and macrophages [1,2], sinusoidal NK cells [3,4] and cells mobilized from the portal blood upon chemotactic stimuli [5]. There is a large literature on the role of liver sedentary macrophages in tumor cell elimination [6]. On the other hand, little is known about the in viv...
متن کاملThe Role of the Sinusoidal Endothelium in Liver Function.
Microvascular exchange in the liver is governed by fenestrations in sinusoidal endothelial cells and can be manipulated pharmacologically. Microvascular exchange is affected in alcoholic liver disease and cirrhosis, the former leading to a loss of fenestrae, the latter to sinusoidal capillarization and thereby to loss of liver function in disease.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hepatology
سال: 2002
ISSN: 0270-9139
DOI: 10.1053/jhep.2002.32528